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Molecular genetic analyses have provided evidence that has helped characterize the carcinogenesis of pancreatic adenocarcinoma. Pancreatic carcinogenesis is a multistep process during which oncogenes are activated, and the function of tumor suppressor genes is lost. K-ras mutations, telomere shortening, loss of p16, loss of p53 and loss of smad4 are thought to contribute to pancreatic carcinogenesis. Recent studies have shown that some new signaling pathway contribute to pancreatic cancer development. Because the model of pancreatic cancer development suggests that several genetic alterations accumulate progressively, the molecular mechanisms underlying this disease should be investigated thoroughly. In addition, we have considered of the appearance of epigenetic and microRNA abnormalities in creating a profile of the molecular genetic mechanisms at work in pancreatic cancer carcinogenesis.

Characterization of the Molecular Genetic Mechanisms that Contribute to Pancreatic Cancer Carcinogenesis