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Currently, anti-angiogenesis drugs are the popular treatment for cancer, which, however, are not without serious drawbacks. Virtually all such drugs are recombinant peptides/proteins or therapeutic antibodies and thus can only be administered via intravenous injection. In addition, these drugs tend to have low stability and short half life in vivo, which demands long treatment at high doses, which in turn renders the therapy expansive and could lead to high occurrences of side effects. Furthermore, these drugs usually target only one, out of many, step or pathway of angiogenesis and are not very effective. Even Avastin, the top-selling anti-tumor angiogenesis drug on the market, can only extend patients’ life span by 4~6 months without a cure. Therefore, it is necessary to develop efficacious, affordable, and orally available angiogenesis-inhibiting drugs. We report here the high-throughput screening (HTS) of over 500 Chinese medicinal herbs and plants in human vessel endothelial cell (HMEC-1) proliferation inhibition assay, which leads to the discovery of several candidate drugs with neovascularization inhibition property. Study on seropharmacology of several medicinal herbs/plants including albizia bark and Semen Vaccariae demonstrated their specific inhibition on HMEC-1 growth, suggesting their potential use as oral drugs for neovascularization inhibition. (seropharmacology as a new screen method to study Chinese medical effects in vitro, which cultive cells by medium containing a serum from animals of oral adminstrated a medicine. It is to be proved that the medicine has the effect after oral the medicine. And it paves a highway for investigation of traditional Chinese medicine. The standardized methodology of seropharmacology was initiaed to help to the exensive application of this technology.) Our study aims to investigate the efficacy and mechanism of such inhibition of albizia bark extracts, its effective moiety and effective monomer in multiple angiogenesis models.

The Effect of Chinese Herb on Tumor Angiogenesis by Inhibiting Vessel Endothelial Cells