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CLL is a hematological malignancy characterized by accumulation of B-1 cells in peripheral lymphoid organs, bone marrow and peripheral blood. It is the most common lymphoid malignancy in the Western World, accounting for 30% of all leukemias. Although the median age at diagnosis is 73, our ever increasing lifespan has put the lifetime risk of developing CLL at 1 in 210 people (NCI, 2011). In addition, since its first description more than 150 years ago, the etiology of CLL remains largely unknown. Hence, it is imperative to study this largely geriatric and incurable disease in more detail.

Altering microRNA miR15a/16 Levels as Potential Therapy in CLL: Extrapolating from the De Novo NZB Mouse Model