English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Mycobacterium avium subsp. paratuberculosis is an acid fast rod, extremely slow growing and mycobactin-dependent for its in vitro growth. This mycobacterium is the etiological agent of the chronic enteritis that affects domestic and wild ruminants, well-known as paratuberculosis or Johne’s disease. In humans, a possible M. avium subsp. paratuberculosis infection has been suggested to be involved in the pathogenesis of Crohn’s disease [1, 2], sarcoidosis; and recently sarcoidosis-like multisystem autosomal-dominant granulomatous disorder (Blau syndrome) [3, 4]. Crohn’s disease encompasses a spectrum of clinical and pathological patterns manifested by focal, asymmetric, transmural, and, chronic granulomatous inflammation affecting the gastrointestinal tract with the potential for systemic and extraintestinal complications. The etiology of Crohn’s disease is thought to be multifactorial, involving an interaction between genetic susceptibility, environmental triggers, and immune-mediated tissue injury. In this regard, there is considerable suggestive evidence to support an environmental factor, such as M. avium subsp. paratuberculosis infection. This evidence includes similarity of the macro and microscopic injuries, bacteriological isolation and molecular biology tests which have allowed the detection of this mycobacterium in intestine, milk and peripheral blood of

Detection of Mycobacterium avium subsp. paratuberculosis in Crohn’s Disease Patients and Ruminants Intestine by In Situ Hybridization