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There is an association between the presence of biofilm-grown microorganisms with delayed wound healing and various diseases such as endocarditis, otitis media, chronic prostatitis, cystic fibrosis, periodontitis, and related infections medical devices and implants responsible for nosocomial infections (Castrillon et al., 2011, Donlan & Costerton, 2002). The latter share common features, although the causative organism and the site of infection are very different, they all evade host defenses and resist treatment with antimicrobials. In general, bacteria in biofilms tolerate high levels of antibiotics compared with planktonic cells (free). The ability of biofilm formation is not restricted to any specific group of bacteria or fungus and is now considered that under ideal conditions all microorganisms can form biofilms (Lasa et al., 2005).

Biofilms: A Survival and Resistance Mechanism of Microorganisms