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Rheum palmatum L., one of the commonly used Traditional Chinese Medicines (TCMs), which is called Dahuang in Chinese, has been successfully used in China for thousands of years. The crude material of R. palmatum called rhubarb was widely used as laxative to treat constipation. Furthermore, it has various other pharmacological actions, such as antibacterial [1, 2], anti-inflammatory [3, 4], antiviral [5], anti-angiogenic [6], antioxidative [7], immunomodulatory [8], protecting effects in rat with chronic renal failure [9] and antidiabetic effects on diabetic mice [10]. Although many investigations have been conducted in the fields of pharmacology, clinical trials, and phytochemistry about rhubarb, researchers still do not know what its effective constituents are, how many compounds are absorbed into blood after intragastric administration of the decoction, and what the fate of the decoction in the body is. The limited knowledge about the metabolism of rhubarb decoction restricts the deeper pharmacological mechanism study and wider clinical use of rhubarb. It was well accepted that TCMs expressed its effects through multi-components and multitargets. Rapid, sensitive and selective analytical method is needed to simultaneous determine of multiple components of TCMs in biological matrix with low concentrations. In recent years, HPLC/ESI/MSn has been proved to be a modern and powerful method for the identification of compounds in biosamples or TCM extracts [11, 12]. Metabolism of rhubarb has been reported [13], but data on pharmacokinetics are scanty. So, our interest was to utilize a solid phase extraction (SPE) and HPLC/ESI/MSn techniques for the detection of potentially active compounds in urine, plasma and tissue samples and for the

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Study on Metabolism of Natural Medical Components In Vivo: Metabolism Study in Rat After Oral Administration of Rhubarb Decoction and Characterization, Identification of the Rat Metabolite of Scutellaria baicalensis