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Viral infections have accompanied humankind from time immemorial. Herpesvirus infections, especially those caused by HSV-1 and HSV-2, are among the most common viral infections at all. The control and treatment of the virus has changed through history, starting with cauterization with hot iron, recommended in ancient Rome, through the most diverse herbal treatments and naturopathic remedies including miracle diets. Fundamental change in the approach to the whole issue occurred in the second half of the twentieth century with discoveries in the field of nucleic acid chemistry. Explanation of nucleic acid structure initiated not only enormous interest and the subsequent boom of molecular biology and genetics but also the formation of a new field of organic chemistry – chemistry of nucleic acid components: nucleosides, nucleotides and oligonucleotides.

intech ebooks

Nucleoside and Nucleotide Analogues for the Treatment of Herpesvirus Infections: Current Stage and New Prospects in the Field of Acyclic Nucleoside Phosphonates