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Hepatocellular death is a key mechanism in alcoholic liver diseases. Although ethanol has been described for many years as capable of increasing membrane fluidity, it is only recently that this fluidizing effect has been reported to be involved in ethanol-induced liver toxicity. In addition, in the last decade, a better understanding of plasma membrane has led to suggest that this membrane is not a random association of lipids, but is rather heterogeneous, with various microstructures enriched in specific components depending on their affinity. Special attention has been paid on lipid rafts that are cholesteroland sphingolipidrich microstructures, conferring them higher rigidity compared to other plasma membrane microdomains. As lipid rafts can also activate or suppress cell signaling pathways, lipid raft discovery provides new arguments for several researchers to revisit the fluidizing effect of ethanol by studying the possible ethanol-induced physical and biochemical alteration of lipid rafts. Thus, in this chapter, we have considered to review the capacity of ethanol to induce a membrane remodeling, depicted as an increase in membrane fluidity and alterations of physical and biochemical properties of lipid rafts, and its relationship with ethanol liver toxicity.

Up-to-Date Insight About Membrane Remodeling as a Mechanism of Action for Ethanol-Induced Liver Toxicity