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The non steroid anti-inflammatory drugs (NSAID) are among the most prescribed because of their analgesic and anti-inflammatory properties [1].The derivatives of the acid aminosalicylic (4ASA and 5-ASA) are used since many years in the treatment of the intestinal chronic inflammatory diseases: Crohn disease and colitis. Aminosalicylic acids exert a direct antiinflammatory action on the intestinal mucous membranes. They do not have any link with the drugs of cortisone family, or with traditional NSAID used for pain and rheumatism. They are also different from the acetylsalicylic acid (Aspirine®). 4ASA also known under the name of paramino benzoic acid (PABA) or paramino salicylic acid (PASA) (figure 1) is employed for the treatment of the ulcerative colitis and Crohn disease. These diseases are characterized by an ignition of the colorectal mucous membrane [2].

intech ebooks

Validation of a Quantitative Determination Method of Paramino-Salicylic Acid by High-Performance Liquid Chromatography and Its Application in Rat Plasma