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A tumor is an abnormal mass of cells, the growth of which exceeds that of the normal tissue. Although most of the skin tumors retain a resemblance to the normal tissues from which they arise, they can show variations in their structure which cause difficulties in establishing pathological diagnosis. In contrast to benign skin tumors, which in most cases remain at the site of their origin and form compact mass of tumor cells, malignant tumors are composed of cells with the ability to invade the basement membrane and metastasize to other organs through blood and lymphatic vessels. Moreover, malignant tumors are often characterized by a more rapid growth and less differentiation, which histologically is characterized by a higher mitotic index and cellular and nuclear pleomorphism (Quinn & Perkins, 2010). Differentiation between benign and malignant skin tumors is one of important questions in terms of diagnostics, prognosis and treatment of the skin lesions. Recently, a variety of molecular markers were shown to be promising in correlation with aggressive and invasive behavior of skin cancers. These involve aberrant expression of p53 (Verdolini et al., 2001), increased expression of transcription factors (Keehn et al., 2004), metalloproteinases (MMPs) (Verdolini et al., 2001), and proliferation markers mib1, Ki-67 (Oh & Penneys, 2004), stem cell markers c-kit, p63 (Laskin & Miettinen, 2003), increased phosphorylation of regulatory proteins and up-regulation of receptors of growth factors (Weigelt et al., 2005). Tumor growth and invasiveness is accompanied by altered cell-cell communications. Thus, aggressive cancers are associated with decreased expression of E-cadherin which correlates with increased expression of desmosomal junction protein desmoglein (Kurzen et al., 2003) and N-cadherin (Gloushankova, 2008; Berx & van Roy, 2009). T-cadherin, a non-classical member of cadherin family, was also suggested to play a role in cancer progression (Andreeva & Kutuzov, 2010; Philippova et al., 2009).

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Malignant Transformation in Skin is Associated with the Loss of T-Cadherin Expression in Human Keratinocytes and Heterogeneity in T-Cadherin Expression in Tumor Vasculature