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Estrogens play a key role in multiple physiological functions in women. They have important actions on bone and lipid metabolism, cardiovascular function, and diffuse effects on other target organs. Estrogens have important roles in cognitive function and influence psychological well-being in women, in development and maintenance of the reproductive system in the female (Gustafsson, 2003). The most potent estrogens are 17┚-estradiol 1, estrone 2 and estriol 3 may have tissue-specific roles (Gruber & Huber, 1999).

Approaches for Searching of Modified Steroid Estrogen Analogues with Improved Biological Properties