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Infectious pancreatic necrosis virus (IPNV) is a fish pathogen and the prototype of the Birnaviridae virus family (Dobos et al., 1979). IPNV causes infectious pancreatic necrosis, an acute and serious disease in juvenile salmonid fish worldwide (Hill and Way, 1995) Birnaviruses possess a bi-segmented, double-stranded RNA genome contained within a medium-sized, unenveloped, icosahedral capsid. The protein products of four unrelated major genes undergo various post-translational cleavage processes to generate three to five different structural proteins (Dobos, 1995). The largest of these proteins (VP1; 90–110 kDa) is encoded by the smaller segment B RNA (Wu et al., 1998). The larger genome segment A contains a large open reading frame (ORF; which encodes VP3 [32-kDa; a minor capsid protein] [Wu et al., 1998], VP4 [28 kDa], and VP2 [the major capsid protein; 46 kDa] [Wu et al., 1998]) and a small ORF, which encodes VP5 (17 kDa; a non-structural protein with antiapoptotic activity) (Hong et al., 2002a; Hong and Wu, 2002c).

Identification of Aquatic Birnavirus VP3 Death Domain and Its Dynamic Interaction Profiles in Early and Middle Replication Stages in Fish Cells