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The lack of a comprehensive aetiology for prostate cancer (CaP), and the need for an effective and inexpensive biological treatment modality, devoid of side-effects has resulted in a multitude of therapeutic trials. None of these has been very satisfying, and they have vaned from focal to invasive therapies for CaP. The progress has been delayed and hampered by the lack of any thorough effort to elucidate the cause of the disease. Such efforts would have speeded up the introduction of more rational therapy modalities. The different incidence of CaP in populations aroused our interest to proceed in a more physiologic way to empirically test different functional f factors, since they are non-toxic, although such an approach is consuming time. It was ethical to test the effect of these natural alimentary components, and follow the patients reaction and laboratory responses. Huggins and Hodges1 had already, in 1941, decisively proven that CaP was a hormone dependent disease, although castration alone was not curative. In 1945 Huggins and Scott performed bilateral adrenalectomies2 after the glands were found to produce DHEA, which could be transformed into testosterone, regarded to have caused recurrent disease. All patients died in a short time postoperatively. However, Huggins did not recognize that this showed the central position the adrenals had in regulating prostate cancer. In this paper we shall review some cases of prostate cancer treated patients. For these we especially follow the shift in FSH, LH, PRL, DHEA, DHEAS, SHBG, plus PSA. The involvement of adrenal glands became evident with an orchiectomized prostate cancer patient with excessively high FSH 120 IU/L and immeasurable PSA. In MRI (magnetic resolution imaging) there was no pituitary adenoma which could explain this high level, but both his adrenal glands were evenly hypertophic. Upon laparatomy the enlargement was due to bilateral zona reticularis (ZR) cell proliferation, while the adrenals other cell structures were normal. These bluish cells with strong green fluorescence had via the hypothalamus stimulated the pituitary to greatly increase FSH and LH, see Case A below with normal laboratory ranges displayed (the row at the top in all cases). The Importance of adrenal ZR cells is unveiled by: A) their marked proliferation after orchiectomy; B) lack of ZR cells in castrated male pigs [eunuchs]; C) markedly decreased number of ZR cells in patients succumb-bing to CaP; D) the hormonal effect in extracts made from ZR cells of castrated boars; E) rapid lethal out-come if CaP patients after

Prostate Cancer, the Long Search for Etiologic and Therapeutic Factors: Dietary Supplementation Avoiding Invasive Treatment