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Allergic diseases affect millions of people around the world. Enhanced prevalence and the chronic characteristics of these illnesses represent an important public health problem. Most prevalent allergic diseases are classified as immediate-type reactions such as urticaria, allergic conjuctivitis, food allergy, allergic rhinitis, anaphylaxis and asthma (Sicherer & Leung, 2004; Fonacier et al., 2010; Sicherer, 2011). The immediate-type reaction terminology is applied to allergic reactions because the symptoms develop few minutes after allergen contact. The immune mechanisms responsible for the initiation of these reactions depend on the production of immunoglobulins (IgG1 and/or IgE) that activate cells such as mast cells, eosinophils and basophils. Once activated, these cells are responsible for release of inflammatory mediators, contributing to the exacerbation and maintenance of the allergic processes (Lampinen et al., 2004). Urticaria is characterized by pruritic, edematous and erythematous lesions that affect 15% to 25% of individuals during their lives. Most of the cases are acute but about 30% of patients present symptoms for more than six weeks and are considered as having chronic disease. Women are more susceptible (75%) than men and only 1% to 5% of the cases are related to IgE-dependent reaction while most of the cases are considered to be induced by physical stimuli or of idiopathic nature, including autoimmune urticaria (Antunez et al., 2006). Allergic urticaria depends on skin mast cell activation which delivers preformed mediators, mainly histamine, few minutes after allergen exposure. On the other hand activated mast cells also produce and deliver neo-formed mediators, i.e., prostaglandin D2 (PGD2) and cisleukotrienes (cisLT) that stimulate inflammatory responses mediated by neutrophils, basophils, eosinophils and T lymphocytes (Funk, 2001; Harizi et al., 2008; Kambe et al., 2010). Another allergic disease of great importance in public health is allergic conjunctivitis. Allergic conjuctivities prevalence in the United States was estimated to affects about 40 million people. Allergic conjunctivitis is marked by the presence of eosinophil cells in conjunctiva mucosa (Bezerra & Santos, 2010). Food allergy, another allergic disorder, is related to the genetic susceptibility of individuals to eggs, peanuts, seafood (e.g. shrimp, lobsters, crabs, squids and mussels milk and others). Oral sensitization

Cissampelos sympodialis (Menispermaceae): A Novel Phytotherapic Weapon Against Allergic Diseases?