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Medial temporal lobe epilepsy (MTLE) is a common syndrome. Many of the cases of medial temporal lobe epilepsy often remain resistant to drug therapy. Surgical resection of the affected temporal lobe is often final option to control/reduce the seizure frequency. Mesial temporal sclerosis which can be unilateral or bilateral is the most common cause of medial temporal lobe epilepsy. Accurate preoperative lateralization of the mesial temporal lobe sclerosis is essential, because the surgical strategy and outcome is distinctive in this group of patients. Currently many non-invasive methods like MRI, EEG and neuropsychological assessment are used to achieve this goal. Number of studies have shown role of various MRI techniques in lateralizing the seizure focus in cases of mesial temporal sclerosis (1-8). Newer quantitative MRI along with qualitative MR techniques has improved the overall sensitivity of MRI for the detection of MTS (9-12). We planned to examine the relative sensitivity of specific MRI sequences in patients with pathologically confirmed MTS.

Multimodal MRI Evaluation in Intractable Epilepsy with Pathologically Confirmed Mesial Temporal Sclerosis