English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Metallic biomaterials constitute approximately 70% 80% of all implant materials, and thus represent a very important class of biomaterials. Among the various metallic biomaterials such as stainless steels and Co-Cr alloys, titanium and its alloys exhibit the best biocompatibility. Consequantly, titanium and its alloys have been the fucus of attension for biomedical materials, especially for use in load bearing implants such as artificial hip joints, bone plates and screws, spinal instruments, and dental implants. The Young’s moduli of metallic biomaterials are generally much higher than that of the human cortical bone (hereafter, bone) (Niinomi, 2002a). If the Young’s modulus of a load bearing implant made of metallic biomaterials is higher than that of the cortical bone, bone atrophy occurs because of the stress shielding between the implant and bone (Sumitomo, 2008). Stress shielding causes loosening of the implants such as artificial joints or bone re-fracture after extraction of the implants. Therefore, the Young’s modulus of the metallic biomaterials must be equal to that of the natural bone. Titanium and its alloys possess lower Young’s moduli than those of other mettalic biomaterials such as stainless steels and Co-Cr alloys. -type titanium alloys, in particular, having a single  phase exhibit much smaller Young’s moduli compared with and ( + -type titanium alloys (Niinomi, 2002b). As such, the -type titanium alloys are particulary promissing for biomedical applications. A number of -type titanium alloys composed of non-toxic and non-allergic elements with low Young’s modulus have been developed and even more are currently under development (Niinomi, 2011a). Much of the current research in the biomaterials field has been directed at lowering the Young’s modulus of the -type titanium alloys for biomedical applications. The mechanical biocompatibility factors such as fatigue strength, fretting fatigue strength, tensile properties, wear resistance, fracture toughness, etc., including the Young’s modulus are very important factors for the practical application of the allloys in biomaterials as well as the biological biocompatibilities (Niinomi, 2008a). Among the mechanical biocompatibility factors, the endurance, i.e., the fatigue strength is one of the most important factors (Niinomi, 20007). The development of metallic biomaterials with improved fatigue strength and a simaltaneously low Young’s modulus is desirable for biomedical applications. The effect of the Young’s modulus of the metallic implant should be clarified by animal experiments prior to medical applications, and recently, these kinds of studies have begun to be implemented (Niinomi, 2002b).

Low Modulus Titanium Alloys for Inhibiting Bone Atrophy