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1.1 Glioma Malignant gliomas are the most common types of brain tumors in adults. These tumors are highly invasive and despite multimodality treatment, the mean survival time of patients is still less than a year (Machado et al., 2005). Gliomas, a cancer of glial cells constitute more than 90% of all primary malignant central nervous system (CNS) tumors. Although gliomas are the most common major subgroup of primary nervous systems tumors, their etiology is less well understood than is the etiology of the other two major subgroups: meningiomas and neuromas. The development of glioma is a complex process with the involvement of both oncogenes and tumor suppressor genes in the accumulation of genetic lesions (Zhang et al., 2005). Brain tumors arise as a result of gradual accumulation of several genetic aberrations in precursor cells which can occur either at the chromosomal level or at the gene expression level (Furnari et al. 1995). Despite considerable efforts to unravel the etiologic basis for this cancer and attempts to find a cure, gliomas largely remain refractory to treatment. Except for a small percentage of cases, the tumors continue to show high morbidity and mortality (Wrensch et al. 2005). The identification and evaluation of the cellular sites in which such genes and their encoded proteins are expressed, could help us to determine how those cellular expression sites are linked to the convoluted circuits of neurons that control brain function. To date, there is major technological challenge in the capability to detect and map genes whose expression is altered either by the disease’s process or by the cells adaptations to resist the disease’s process (Bloom et al., 2004).

The Expression of BORIS Protein in a Newly Established Primary Glioma Cell Culture Line