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The gastrointestinal system consists of a hollow muscular tube starting from the oral cavity, where food enters the mouth, continuing through the pharynx, oesophagus, stomach and intestines to the rectum and anus, where faeces pass out. The primary purpose of the gastrointestinal system is to break down food into nutrients, which together with water can be absorbed to feed the body cells. In the case of gastrointestinal disease or disorders, these functions of the gastrointestinal tract are not achieved successfully, discussed in the subsequent sections of this chapter. The innermost layer of the gastrointestinal system is the mucosa, which is lined with specialised epithelial cells, supported by an underlying connective tissue layer called the lamina propria, where infiltrating leucocytes, in particular, myeloid linage leucocytes are often seen.

intech ebooks

The Diagnostic Value of Colonoscopy in Understanding Inflammatory Mucosal Damage in Patients with Ulcerative Colitis and Predicting Clinical Response to Adsorptive Leucocytapheresis as a Non-Pharmacologic Treatment Intervention