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Human Immunodeficiency Virus (HIV) is the causative agent of AIDS (Acquired Immune Deficiency Syndrome). Currently, the infection by HIV is considered as one of the major problem of public health and social stability. The scale of HIV/AIDS epidemic has exceeded all expectations since its identification 30 years ago. Currently, according to the report on HIV/AIDS by UNAIDS and World Health Organization (WHO) in 2009, we estimated approximately 33 million people are currently living with HIV-1 and about 25 millions have already died (Piot, Feachem et al. 2004). HIV infection leads to a decline in the number of T helper CD4 cells leading to a progressive dysfunction of the immune system. This weakening of the immune system results in the development of opportunistic infections leading to death of the patient. Despite prevention policies and anti-retroviral therapies, AIDS still remains one of the most serious humanitarian crises that we have never known.

HIV Infection «HIV Tat Protein, a Key Factor in Pathogenesis and Immune System Dysregulation: Implication of IL-10»