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The cell cycle is the process of accurate self-reproduction and proliferation of a cell. It is the basis of the growth, development, heredity and evolution of organisms. Misregulation of the cell cycle may result in malignant cell proliferation, tumorigenesis or cell death. In this chapter, we mainly discuss the coordination regulations between DNA replication initiation and other cell cycle events that ensure genomic integrity. Recent breakthroughs have uncovered more and more DNA replication licensing machinery proteins (ORC, Cdc6, Cdt1, geminin, etc.) functioning in other cell cycle events, including centrosome replication, mitotic events, transcription and so on.

The Coordination between DNA Replication Initiation and Other Cell Cycle Events