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1.1 Actual thyroid disease demographics Thyroid diseases increase in a ubiquitous global phenomenon suspected to further rise in the upcoming decades (Dua et al. 2008). Thyroid cancer is the most common endocrine malignancy, representing 2% of all malignancies. A rapid global rise in its incidence has been seen in recent decades, especially concerning the papillary type, which has been increasing in several countries (Liu et al. 2001; Reynolds et al. 2005; Davies and Welch 2006; Enewold et al. 2009; Kilfoy, Devesa et al. 2009; Kilfoy, Zheng et al. 2009). An estimated 44,670 new cases of thyroid cancer are expected to be diagnosed in the United States of America in 2010, with three out of four cases occurring in women. The incidence rate of thyroid cancer has been increasing sharply since the mid-1990s, and it is the fastest growing cancer in both men and women, as well as the ninth most common human malignancy in the USA (American Cancer Society: Cancer Facts and Figures 2010). The reasons for the increase in occurrences of this type of cancer are still unclear and controversial. Earlier studies suspected that the upward trend was caused by the widespread use of radiation therapy for benign conditions of the head and neck among children and adolescents from the early 1920s to the late 1950s (Weiss 1979; Pottern et al. 1980). Other studies suggested that this trend could be associated with atmospheric nuclear fallouts (Catelinois et al. 2004; Gilbert et al. 1998; Kazakov, Demidchik, and Astakhova 1992; Kerber et al. 1993; Takahashi et al. 2003) or constant diagnostic X-ray exposures (Prokop 2001; Ron et al. 1995) suffered especially by children (Brenner et al. 2001; Golding and Shrimpton 2002; Maitino et al. 2003). More recent studies suggested that the prevalence of thyroid nodules depends on the screening method and population evaluated according to geographic regions and racial groups, indicating that the widespread use of ultrasonography and socioeconomic indicators of health care access could be the major players in this new demography of the thyroid cancer (Morris and Myssiorek 2010; Sprague, Warren Andersen, and Trentham-Dietz 2008). The steep increase in thyroid cancer is certainly related to better cancer detection by ultrasonography and other imaging techniques in a population growing older, as well as a larger and easier access to health care and robust laboratory diagnostic tools such as TSH and thyroid antibody dosages (Davies and Welch 2006; Ward and Graf 2008). However,

Thyroid Disruptors: How They Act and How We React