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Upon different external stimuli including bacteria and virus infection, and internal stimuli including both self-damaged products from trauma, burn injury, surgery, cancer mediated inflammatory disorders, exhausting exercises, child delivery and stroke as well as different immune diseases, an organism need to react in order to continuously preserve an equilibrated thermodynamic state, namely homeostasis. This process is highly conserved in living beings. The absence of this global state generates pathological processes and ultimately, the death.

IL-22 Induces an Acute-Phase Response Associated to a Cohort of Acute Phase Proteins and Antimicrobial Peptides as Players of Homeostasis