English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Malignant melanoma is a serious type of skin cancer that begins in the pigmentation system of the skin. Malignant melanomas, characterized by their high capacity for invasion and metastasis, are one of the most frequent forms of skin cancer. Primary cutaneous melanomas have been divided into four groups based on histopathology: superficial spreading melanoma, nodular melanoma, lentigo maligna melanoma and acral lentiginious melanoma1. Superficial spreading melanoma is the most common type of melanoma and grows outwards at first to form an irregular pattern on the skin with an uneven color. It usually starts by spreading out across the surface of the skin in what is known as the radial growth phase. Nodular melanoma occurs most often on the chest or back. It tends to grow deeper into the skin and grows quite deeply if not removed. This type of melanoma is often raised above the rest of the skin surface and feels like a bump. It may be very dark brownblack or black. Lentigo maligna melanoma is most commonly found on the face of elderly people. It grows slowly and may take several years to develop. Acral lentiginious melanoma is usually found on the palms of the hands, soles of the feet or around the toenails. Although melanoma is almost always curable in its early stage, it may be too late if the melanomas spread to other parts of the body. Early diagnosis of melanoma is therefore very important, and it is necessary to develop additional methods of melanoma therapy2. Malignant melanoma usually develops from the transformation and proliferation of melanocytes that normally reside in the basal cell layer of the epidermis. It also develops when the melanocytes no longer respond to normal control mechanisms of cellular growth. The melanocytes may then invade nearby structures or spread to other organs in the body (metastasis), where again they invade and compromise the function of that organ. To better understand the molecular and cellular mechanisms involved in the progression of cutaneous melanoma, human malignant melanoma cells have been widely used as a melanoma skin model for in vitro testing. This is because it is highly reproducible, quantifiable and easily handled in culture. Not only is it a structural cell model that closely parallels the progression of melanoma in vivo, it is also a cost-effective alternative to animal

Molecular Profiling of A375 Human Malignant Melanoma Cells Treated with Kojic Acid and Arbutin