English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Kidney transplantation is the preferred therapy for most patients with end-stage renal disease (Sui et al., 2008; Turgeon et al., 2009). Transplantation improves both quality of life and survival (Chavez et al., 2008). Unfortunately, the rate of renal allograft rejection remains important. With the aim of reducing the level of transplantation failure, several researches were achieved to elucidate the immunological mechanisms involved in this process. Thus, it was well established that allograft rejection is an immune response strongly depending on T cells proliferation. In fact, T lymphocytes play a crucial role in the initiation and the regulation of the adaptive immune response to foreign or native antigen (Vincenti, 2008). Herein, we focused on the costimulatory molecules: CTLA-4 and CD28: two receptors of T lymphocytes, and CD86: their common ligand on the antigen presenting cells (APC).

Evaluation of CTLA-4, CD28 and CD86 Genes Polymorphisms in Acute Renal Allograft Rejection among Tunisian Patients