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Gastric ulcer disease remains widespread; a stressful lifestyle and non-steroidal antiinflammatory drugs (NSAIDs) make significant contributions to this pathological situation (Glavin et al., 1991; Hawkey, 2000; Laine et al., 2008). Despite indubitable advances in elucidation of the pathogenesis of gastric ulceration, there are gaps in our understanding of ulcerogenesis, particularly the role of key hormonal system of adaptation: the hypothalamicpituitary-adrenocortical (HPA) axis.

Activation of the Hypothalamic-Pituitary-Adrenocortical Axis as a Gastroprotective Component of Stress Response