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Tropical herb extracts, such as Andrographis paniculata, Eurycoma longifolia Jack and Orthosiphon stamineus, which have enormous beneficial health effects need to be made available in a convenient and affordable tablet form. Information on the powder extract characteristics during compression is lacking and would be useful in investigations of powder deformability for optimizing operating conditions. The current market value of herbal products for traditional and complementary medicine is estimated to be between USD 40 to 100 billion with an average growth rate of 15 to 20% each year (Abdul Aziz et al., 2004). Andrographis paniculata (locally known as ‘hempedu bumi’ or ‘akar cerita’) has analgesic, anti-malaria, anti-inflammatory, anti-neoplastic, anti-ulcerogenic, anti-bacterial, febrifuge, anti-platelet, anti-diarrhoeal anti-thrombotic, anti-diabetic, and anti-hypertensive properties (Ahmad and Asmawi, 1993). The roots of Eurycoma longifolia Jack are traditionally used for curing fever, mouth ulcers, and intestinal worms, and as a general tonic after childbirth, and are believed to be effective for treating hypertension and malaria. Studies have shown that Eurycoma longifolia Jack possesses sexual enhancement and aphrodisiac properties (Sambandan et al., 2006). Orthosiphon stamineus, or ‘misai kucing’, has also been scientifically proven to have anti-hypertensive, anti-inflammatory, and diuretic properties, and has also been proven to be beneficial for urinary tract ailments, renal stones, arteriosclerosis, nephritis, diabetes mellitus, hypertension, rheumatism, tonsillitis, and menstrual disorders (Jagarath and Ng, 2000). Currently, Orthosiphon stamineus is categorized as one of the herbs with a great potential for commercialization in Malaysia due to its easy cultivation and its validated health benefits, particularly in treating ailments associated with the kidney and urinary system (Jagarath and Ng, 2000). Most of the research conducted on these herbs so far has been limited to their chemical and medicinal properties. This work attempted to obtain scientific and engineering data to determine the technical feasibility and economic viability of producing solid oral dosage

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A Comparison of the Direct Compression Characteristics of Andrographis paniculata, Eurycoma longifolia Jack, and Orthosiphon stamineus Extracts for Tablet Development