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The review aims to emphasize the state of art of herbicide resistance mechanisms in weeds, when ourdays realities confront us with crop productions in continuous expansion in EU and worldwide. Regarding sustainable agriculture and plant biodiversity maintenance as premise for successful development in the future, the virtual environmental threat produced by a large diversity of herbicides in use appears as entitled concern. This reality is exacerbated by another phenomenon: the development of herbicide resistant weeds reported more and more often in last four decades. In this way, even herbicides still represent the most important and effective tool in controlling weeds, in many areas, their field value decreased. The alteration produced, often as punctiform mutations, in weed genotypes in order to counteract the herbicide attacks, led to development of resistant weed biotypes that may produce huge harmful environmental effects, besides yield loss. One of the most important reasons of this phenomenon is represented by administering the same herbicide for many years to the same culture in the same cultivation field. The situation is aggravated when the herbicide has only one site of action in herbicide genome (Sigematsu et al., 1989; Kremer et al., 1999; Owen et al., 2005; Powels et al., 2010). This underlines the importance of obtaining a better understanding of the mechanism that represents the basis of resistance, in order to successful fighting against this phenomenon. It was elucidated by emphasizing the biochemical processes and genetic mechanisms that occur in plant in order to develop defending mechanisms. The genetic processes involved in weed genome react to environmental stimuli, as the attack of active principle from herbicides. Usually, the gene/genes that metabolize the active substance/substances from the herbicide are naturally multiplied of several hundred times, compared to the genotype of a plant that is not resistant. Now, gene amplification is one of the well known mechanisms of resistance against herbicides (Vila-Aiub et al., 2003; Oroian, I., 2008; Ge et al., 2010). These mechanisms once understood can be counteracted by suitable measures taken at different levels. Some of the most important crop management strategies that could contribute to reduce the appearance and/or decrease of the frequency of this phenomenon consist in: using herbicides only when necessary, rotate crops and herbicides site of action, using combined herbicide administration system, combine mechanical weed control with chemical treatment (Paoletti et al., 1995; Berca M., 2007).

Brief Approach of Herbicide Resistance in Context of Crops Development Worldwide