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Human bone marrow or human umbilical cord vein derived-mesenchymal stem cells (hBM-MSCs or hUC-MSCs) have known as a potentially useful cell type for clinical therapeutic applications. We investigated two-pore domain potassium (K2P) channels in these cells. K2P channels play a major role in setting the resting membrane potential in many cell types. Among them, TREK1 is targets of hydrogen, hypoxia, polyunsaturated fatty acids, antidepressant, and neurotransmitters. We investigated whether hBM-MSCs and hUC-MSCs express functionalTREK1 channel using RT-PCR analysis and patch clamp technique. Potassium channel with a single channel conductance of 100 pS was found in hUC-MSCs and BM-MSCs and the channel was activated by membrane stretch (-5 mmHg ~ -15 mmHg), arachidonic acid (10 μM) and intracellular acidosis (pH 6.0). These electrophysiologicalproperties were similar to those of TREK1. Our results suggest that TREK1 is functionally present in hBM-MSCsand hUC-MSCs, where they contribute to its resting membrane potential.

Functional expression of TREK1 channel in human bone marrow and human umbilical cord vein-derived mesenchymal stem cells