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This study examined the anti-cancer activity of gallic acid(GA) isolated from P. suffruticosa. was analyzedby ESI-MS, 1 H-NMR, and 13 C-NMR. The anti-cancer activity was evaluated by measuring the cancer size in CT-26 cancer-allograft mice treated with GA(100 ㎎ / ㎏ p.o) for 14 days. The change in body weight, acute toxicity, weightchange of the liver and spleen and biomaker of the liver were evaluated in the mice after the GA treatment. As aresult, the cancer size of the CT-26 cancer-allograft mice treated with GA decreased significantly compared to that of the cancer mice without significant changes in weight loss (p<0.05) and acute toxicity. The weight of the liver and spleen and ALT, AST and LPO levels increased by cancer were decreased significantly after the GA treatment, and the GSH levels decreased by cancer were increased significantly with the GA treatment (p<0.05). Therefore, GAcould be an attractive lead for the development of anticancer agents. Key Words : Anticancer agents, Biochemical markers, Gallic acid, Mice, Paeonia suffruticosa.

Anti-Cancer Effect of Gallic Acid in CT-26 Cells Inoculated Cancer Bearing Balb/C Mice