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In order to develop anti-wrinkle agent, we measured the anti-oxidative activity of gallic acid (GA) from Paeonia suffruticosa Andrews and investigated its cytotoxicity in HaCaT cells and then investigated its effect on tumor necrosisfactor alpha (TNF-α)-induced matrix metalloproteinase-1 (MMP-1) mRNA, protein expressions and secretion in samecells. GA showed anti-oxidative activity with IC 50 of 30 μg/mL and its activity was higher than that of butylatedhydroxyanisol (BHA). GA showed weak cytotoxicity with high concentration (200 μg/mL) in HaCaT cells. MMP-1mRNA, protein expression and secretion induced by tumor necrosis factor alpha (TNF-α) in HaCaT cells were significantly decreased by treatment of GA with dose-dependent manner( p <0.05). Therefore, our findings suggest thatGA can be useful as an active ingredient for cosmeceuticals of anti-wrinkle effects. Key Words : Anti-wrinkle effects, Gallic acid, Matrix metalloproteinase-1 (MMP-1), Paeonia suffruticosa * Corresponding Author : Pom-Ho Kim(Wonkwang Univ.)Tel: +82-10-2300-8592 email: biopalpal@naver.comReceived October 21, 2013 Revised October 31, 2013 Accepted November 7, 2013

Inhibitory Effect of Gallic Aicd on TNF-α-induced matrix metalloproteinase-1 (MMP-1) in HaCaT Cells