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retardation, and bulbar/pseudobulbar signs. The recent study showed that these clinical symptoms and signs may vary according to age at onset and GFAP mutation site. This study by Prust et al. includes a review of 218 cases, includ­ ing 30 new cases of Alexander disease, with evidence suggesting that early age of onset (often before 4 years) is frequently asso­ ciated with seizures, macrocephaly, encephalopathy, paroxysmal deterioration, or failure to thrive. However, only a few studies emphasizes in distinguishing a neonatal form of Alexander disease from early onset type where specific clinical symptoms exhibit during neonatal period. The neonatal form can be distinguished from others by frequent intractable seizures in A Neonatal Form of Alexander Disease Presented with Intractable Seizures and Obstructive Hydrocephalus