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As a new cryptolepine derivative containing indole and quinoline structures, SYUIQ-5 has been reported to induce and stabilize G-quadruplex, inhibit c-myc promoter and telomerase activity. This study was to investigate autophagy induced by a G-quadruplex ligand SYUIQ-5 and its mechanisms in nasopharyngeal cancer cells.

A G-quadruplex ligand SYUIQ-5 induces autophagy by inhibiting the Akt-FOXO3a pathway in nasopharyngeal cancer cells