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FHIT gene methylation leads to down-regulation of its expression in hepatocellular carcinoma (HCC) cells. This study was to detect the expression of FHIT mRNA and protein in HCC cell line HepG2 after treatment of methylase inhibitor 5-Aza-2'-deoxycytidine (5-Aza-dC), and observe the effect of 5-Aza-dC on the proliferation of HepG2 cells.

Effect of 5-Aza-dC on FHIT gene expression in hepatocellular carcinoma cell line HepG2