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Invasive carcinorna ef the mamrnary gland with systemic rnetastases was found in a captive nulliparous female Califomia sea lion, over 17 years olcl. Numerous yellowish white masses of various sizes were discovered in the mammary region and many organs. Microscopically, all the masses consisted of epithelial tumor cells that were irregular in size and shape. Epithelial turnor cells had often invaded adjacent tissues and vessels, especially lymphatics, The tumor cells were arranged mainly in tubular to papillary forrnations with some solid sheets in the mammary region, whereas principally solid formations were found in the metastatic regions. We diagnosed this as a case of simple tubulopapMary to solid carcinoma of mammary gland with systemic metastases, Key words/ California se lion, adenocarcinoma, mammary gland lpn, J. Zoo. vafildl. Med, 12(2) :123-126, 2007 The California sea lion (Zalophus catijbrnianus) is a species classified in Family Otariidae, Order Carnivora [1], Mammary gland tumor is rather well known in dogs and cats that are classified also in Order Carnivora, and various studies and treatments have been reported [2, 3]. In pinnipeds, however, although various neoplasia were reported [4-12], the reports of mammary gland tumor are limited [13, 14]. This study introduces $ystemic metastasis of invasive carcinoma of the inammary gland in a captive California se lion, The affected sea lion had been kept for about 17 years before death at Marine World Urninonakamichi in Fukuoka City, Fukuoka Prefecture, Japan. The animal was a female without an experience of pregnancy. The clinical signs including loss of appetite and aetivity had developed gradually, although the anirnal was treated with antibiotics for several weeks. A subcutaneous mass had been palpable in her right axilla until death. She died on March 18, 2005, and the entire course was about a month from the time of noticed loss of appetite until death, The animal was transported by air to the National Museum of Nature and Science and necropsied within 24 hours after death. Body length and wejght measured prior to the necropsy were 165cm and 66.7kg, respectively. The animal was extremely ernaciated, otherwise the overal] pelage appeared healthy (Fig. 1). Numerous masses ofvarious sizes, the largest of which was 17 cm in diameter and situated near the right anterior nipple, were extensively discovered subcutaneously in the mammary region. These rnasses possessed dilated cysts containing sorne brownish-yellow viscous fluid, however, no cutaneous ulcer and iajury were observed. Gross appearances of these rnasses varied widely from soft to firm in texture, and yellow to pale brown in color. Subcutaneous tissues were extensively and severely edernatous and congestive. Many circumscribed round masses up to 2 cm in diameter and yellowish-white in color, were also found extensively in other areas including the heart, lungs, kidneys, stomach, small and large intestines, adrenal glands, thyroid gland, pancreas, genital organs, many lymph nodes, peritoneum and even skeletal muscles (Fig, 2). However, there were few masses in the liver and the spleen. Severe pulmonary congestive edema, and swollen, fragile and discolored ]iver were observed. Collected tissues were fixed in 1O% neutral buffered forrnalin, embedded in pararnn, sectioned at 4 pa m, and stained with hematoxy]in and eosin (HE) for histopathology, Selected

A Case Report of Carcinoma of Mammary Gland with Systemic Metastases in a Captive California Sea Lion (<i>Zalophus californianus</i>)