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The present study aimed to determine the possible mechanisms of the peripheral antinociception of the aqueous extracts of Dicranopteris linearis (AEDL), Melastoma malabathricum (AEMM) and Bauhinia purpurea (AEBP) leaves in mice. Briefly, the antinociceptive profile of each extract (300, 500, and 1000 ㎎/㎏; subcutaneous (s.c.)), was established using the abdominal constriction test. A single dose (500 ㎎/㎏) of each extract (s.c.) was pre-challenged for 10 min with various pain receptors’ antagonists or pain mediators’ blockers and 30 min later subjected to the antinociceptive assay to determine the possible mechanism(s) involved. Based on the results obtained, all extracts exerted significant (p 1A , dopaminergic receptors).

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Effects of various receptor antagonists on the peripheral antinociceptive activity of aqueous extracts of Dicranopteris linearis, Melastoma malabathricum and Bauhinia purpurea leaves in mice