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Nonrapid eye movement (NREM) sleep desaturation may cause neuronal damage dueto the withdrawal of cerebrovascular reactivity. The current study (1) assessedthe prevalence of NREM sleep desaturation in nonhypoxemic patients with chronicobstructive pulmonary disease (COPD) and (2) compared a biological marker ofcerebral lesion and neuromuscular function in patients with and without NREMsleep desaturation.

Brain Damage and Motor Cortex Impairment in Chronic Obstructive Pulmonary Disease: Implication of Nonrapid Eye Movement Sleep Desaturation