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Ethanol extracts from Rhododendrom brachycarpum and Abies koreana were investigated fortheir anti-allergic activities using RBL-2H3 cell line. After treatment with ethanol extracts of variousconcentrations on the immune response induced mast cell by concanavalin A (Con A), the expressions of cytokine interleukin-4 (IL-4), interleukin-13 (IL-13) were determined by using RT-PCR and the degranulation of mast cells was determined by measuring β-hexosaminidase release. Expression level of IL-4 was decreased by the extract from Rhododendrom brachycarpumin 10 -7 , 10 -5 and 10 -3 % concentrations. Expression level of IL-13 was also decreased by both extracts.β-Hexosaminidase release by RBL-2H3 cells was inhibited at the 10 -5 and 10 -3 % concentration of extracts from Rhododendrom brachycarpum and Abies koreana, respectively. These results demonstrate that ethanol extracts of Rhododendron brachycarpum and Abies koreana exert anti-allergic effects by regulating the reduction of IL-4 and IL-13 genes expressionand also the secretion of β-hexosaminidase. Keywords : Rhododendron brachycarpum, Abies koreanaE.H. Wilson, IL-4, IL-13, β-hexosaminidase, extractives, anti-allergic activity

Inhibitory Effect of Extracts from Rhododendron Brachycarpum and Abies Koreana E.H. Wilson on Degranulation and Cytokine Expression in RBL-2H3 Cells