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,             (Hancock and Diamond, 2000),    , T  B cell    (Seo et al., 2009).  ,        , 1  bacteria virus             interleukin (IL)-6, IL-1β  tumor necrosis factor-α (TNF-α)  cytokine ,        (Yu et al., 2012a).     ,        T cell    , T  B cell  (Yoon, 2008).  CD4+ T cell helper T (Th)   ,         cytokine    .  Th cell Th1  Th2 cell       (Mosmann and Coffman, 1989).   Th1 cell  cytokine IL-2, IL-12, interferon-γ (IFN-γ)  TNF-α ,    , Th2 cell  cytokine IL-4, IL-5, IL-6, IL-10          (Katsuwonus pelamis)         ······ ···*

Immuno-stimulating Activities of Skipjack Tuna Katsuwonus pelamis Cooking Juice Concentrates on Mouse Macrophages and Spleen Cells