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(dementia)                  (Alzheimer's disease)      .            ,       .          ,   ,   (neurofibrillary tangle)  (neuritic plaque)   .        -(β-amyloid)  40-42         ,         (Hardy, 1997; Selkoe, 1997). - β-secretase γ-secretase       (Amyloid Precursor Protein: APP)      . APP        presenilin-1 (PS1)   PS1     (Wolfe et al., 1999). , APP    β-secretase  BACE1 (EC 3.4.23.46)    -    (Sinha and Lieberburg, 1999).  BACE1        (Lin et al., 2000).                     . BACE1    human aspartic protease BACE2 (EC 3.4.23.45) down BACE2    ····*

Overexpression and Refolding of BACE2