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1/3   .       ,                 .  Ohayon (2002) Kupfer (1997)      30-35%   ,          .       ,        .     , , ,   ,            .    Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV)  “   ,         ”  ,     78%      (Bastien et al., 2004).       (Adenosine), (acetyl choline), (serotonin, 5-Hydroxytryptamine), (melatonin, N-acetyl-5-methoxy-tryptamine), gamma amino butyric acid (GABA)             .         (benzodiazepine)  , (non-benzodiazepine)     .          .          gamma-amino butyric acid (GABA)    , GABA   GABA  Cl    .    ,     (Claude, 2002).       zolpidem, zaleplon, eszopiclone GABA

Stress Relaxation and Sleep Induction Effect of Fermented Sea Tangle Saccharina japonica and Oyster Crassostrea gigas Powder