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We compared the fatty acid compositions including the n-3 and n-6 polyunsaturated fatty acids families in the red blood cell membranes of 26 healthy normal subjects to those with coronary heart disease. The main finding was a significant decrease in the level of docosahexanoic acid (DHA, 22:6 n-3) in coronary heart disease patients. In addition, an increase in n-6/n-3 ratio, and a decrease in the ratio of 22:6/18:3 (n-3) and in omega-3 index was also observed in coronary heart disease patients. The reduction in 22:6/18:3 (n-3) ratio suggests a defect in the elongation and desaturation steps in the n-3 series. The findings in this study also suggest that the low dietary value of fish from Bahrain water may have resulted in a modest dietary intake of DHA and eicosapentanoic acid (EPA, 20:5 n-3), which might have been the reason behind the high incidence of coronary heart disease in Bahrain.

Fatty Acid Profile of the Erythrocyte Membranes of Healthy Bahraini Citizens in Comparison with Coronary Heart Disease Patients