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In this study, the authors produced self-aggregates of highly hydrophobic phospholipid polymers consisting of 2-methacryloyloxyethyl phosphorylcholine (MPC) and stearyl methacrylate (SMA). MPC/SMA copolymers (PMS) self aggregated in a solvent consisting of 1-propanol and water (in 1:4 (w/w)). When alcohols other than 1-propanol were used, no homogeneous self-aggregate solution was obtained. The average diameter of PMS self-aggregates varied from 10 to 40 nm depending on the MPC content in PMS. The PMS self-aggregate was stable, and the diameter showed no changes even when the solution was stored at 60°C or 4°C for 3 months. The PMS showed high solubilization ability and solubilized hydrophobic compounds, such as tocopherol acetate and coenzyme Q10, in aqueous solutions. PMS that contained 50 unit mol% of SMA (PMS5050) showed the highest solubilization ability among PMS of different SMA contents. In spite of the high solubilization ability, PMS self-aggregates showed low surface activity and almost no cytotoxicity, showing that the PMS self-aggregates are promising biocompatible solubilizer.

Self-aggregates of Highly Hydrophobic Phospholipid Polymers in Aqueous Solution