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The effects of dietary administration of butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) on acetaminophen (APAP)-induced hepatic metabolism in rats were examined. The administration method involves providing the rats with 0.5% each of BHA and BHT separately added to their diets for 7 days. Based on the results of the plasma aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities for dietary administration, BHA and BHT in the diets fully prevented APAP-induced hepatotoxicity (500 mg / kg IP). By adding BHA and BHT to feedstuffs, hepatic UDP-glucuronosyltransferase (UDP-GTase) remained activated in the rats. The excreted amount of APAP-glucuronide increased and the residual APAP declined in the urine of the rats. After APAP administration in BHA or BHT pretreated rats, the excretion in plasma reached the largest amount for APAP-glucuronide at 2-4 h and APAP-sulfate at 6 h. It was clear that BHT excelled over BHA in playing the role of promoting hepatic metabolism. Data thus obtained showed the proposed different metabolisms in APAP-induced hepatotoxicity between BHA and BHT.

journal of oleo science

Differences between the Antioxidation Effects of Butylated Hydroxyanisole and Butylated Hydroxytoluene on Acetaminophen - Induced Hepatic Metabolism in Rats