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D-Psicose, a C-3 epimer of D-fructose, is one of the "rare sugars" present in small quantities in commercial carbohydrate complex or agricultural products. In this study, we investigated effects of supplemental D-psicose on glucose tolerance and secretion of adipocytokines in rats fed a high-fat diet versus a low-fat diet. Twenty-four male Wistar rats (4 weeks old) were divided into four groups. Each group was fed a high-fat (25% fat) or a low-fat (5% fat) diet containing 5% D-psicose or cellulose for 16 weeks. Abdominal adipose tissue weights and carcass fat content were greater in rats fed the high-fat diet. However, D-psicose supplementation did not increase body fat accumulation compared to cellulose. Glucose tolerance decreased with time, and D-psicose supplementation did not improve glucose tolerance. Leptin, adiponectin and tumor necrosis factor-a levels in serum were the same among the four groups. These results suggest that supplemental D-psicose has no anti-diabetic effect in rats.

Effects of Supplemental D-Psicose on Glucose Tolerance and Serum Adipocytokine Levels in Rats Fed a High-Fat Diet or a Low-Fat Diet