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The purpose of this study was to review the safety of long-term excessive ingestion of Garcinia extract. For 12 weeks, a dosage of 5000 mg Garcinia extract powder (3000 mg/day as (-)-hydroxycitric acid [(-)-HCA]) was administered to healthy subjects (men 24, women 24). Hematology, hemobiochemistry, endocrinology and urinalysis were carried out every four weeks. Endocrinologically, serum inhibin B increased in men (P<0.05), from 162.1 ± 46.2 pg/mL to 186.7 ± 61.6 pg/mL. In addition, Follicle Stimulating Hormone (FSH) increased (P<0.05), from 4.68 ± 2.65 mIU/mL to 5.18 ± 2.75 mIU/mL. It is hard to conceive the changes had a testiculus influence, because the changes were very slight and no reciprocal relationships existed between them. In women, no significant change of sex hormone was noted and no influence on menstrual cycles was observed. Neither remarkable changes in hematology, hemobiochemistry and urinalysis nor adverse events were observed. These findings support the safety for humans of long-term excessive administration of Garcinia extract (3000 mg/day as HCA, 12 weeks) was high.

Safety of Garcinia cambogia Extract in Healthy Volunteers: High-Dose Administration Study II