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Effects of Witepsol base, P. E. G. base and aminophylline suppositories (Witepsol base, P. E. G. base) on the rectal mucous membrane in rabbits were investigated. These suppositories were administered once in a single dose or once a day for 2 weeks. The rectum extirpated 6 hrs after last insertion was examined with unaided eyes and optical and scanning electron microscopes. As a result, no damage by aminophylline suppositories and bases was observed, and irritative effect of Witepsol base was in about the same degree as that of P. E. G. base.

Effects of Aminophylline Suppositories Prepared in Hospital Pharmacy on the Rectal Membrane