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Grinding tablets is often required on dispensing. Weight loss in tablet content caused in that process was investigated with several uncoated and coated tablets. Two grinding methods, one using a mortar with pestle and the other using a tablet grinding machine, were conducted and the test results were compared with each other. The loss in weight varied depending on number of tablets employed: the larger the number of tablets becomes, the smaller the loss in weight is, and vice versa.That tendency was observed in both methods. However, the loss in weight by the method using a mortar with pestle was always greater than that by the method using a tablet grinding machine. The loss in weight of the tablets on grinding in a mortar with pestle together with powder was smaller than that of the tablets without powder.

Loss in weight by grinding tablets on dispensing