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Cherry bark extract oral liquid preparations are widely used. These preparation are obtained by adding senega syrup, apricot kernel water, and water to cherry bark extract (Brocin®) We investigated microbial contamination in the residual fluid after patients had taken cherry bark extract oral liquid preparations. Of 29 examined samples, 15 (52%) showed microbial contamination with a viabie count >20 CFU/ml. The viable count level was 104-105CFU/ml in three samples (10%), 103CFU/ml in one (4%), and 10-102 CFU/ml in 11 (38%). To prevent microbial contamination in these preparations, it is necessary to avoid the use of the method in which water is added to obtain a daily liquid preparation volume of 100 ml. Specifically, the addition of water should be avoided, or the water volume should be decreased to obtain a daily liquid preparation volume of 20-40 ml.

Bacterial Contamination of Cherry Bark Extract Oral Liquid Preparations and its Prevention.