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(Received March 16,1989) The compatibilities of ethanolamine oleate(EO)injection with 4 kinds of contrast media (meglumine amidotrizoate,iopamidol,iohexol and ioxaglic acid),distilled water for injection or isotonic sodium chloride solution which might be admixed in the sclerosing treatment of esophageal varices were tested.We observed the changes in appearance,pH,osmotic pressure, viscosity and the capacity of fluoroscopic visualization,and quantitatively analysed oleic acid and ethanolamine at regular intervals.The capacity of visualization was measured by X-ray fluoroscopy.No change was observed in the mixtures of EO with iopamidol,iohexol or distilled water for injection.The viscosity of the mixtures with iopamidol or iohexol were comparatively low value at 3.3,2.7 cP respectively,and the discharge of these two mixtures in the process for injection might be easy.But when admixed with meglumine amidotrizoate, ioxaglic acid or isotonic sodium chloride solution,the change in the appearance(whitening or separation into two phases) was observed.

Compatibility of ethanolamine oleate injection with other preparations.