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The effect of storage condition and the quality of wrapping paper on the moisture protection of pharmaceutical preparations were investigated using a couple of pulverized hygroscopic pharmaceuticals and a few powder preparations having different critical relative humidity. Sodium valproate or potassium L-aspartate tablet was pulverized. Powder preparations used were potato starch, lactose, sodium chloride and fructose. 9 different wrapping papers having various grades of moisture permeability were adopted. The results of the study were as follows:1) The moisture permeation of wrapped powder preparations is affected by storage conditions. 2) Amount of absorbed moisture decreased when wrapping papers, with low moisture permeability were used; therefore, it became clear that the selection of suitable wrapping papers is important to protect powder preparations against the moisture permeation.

Moisture protection for powder preparations; Effect of storage conditions and the quality of wrapping paper.